NMNAT1 Is Essential for Human iPS Cell Differentiation to the Retinal Lineage
These results indicate that NMNAT1 was dispensable for neural lineage differentiation but essential for the commitment of retinal fate differentiation in hiPSCs. The NMNAT1-NAD-PARP1 axis may play a critical role in the appropriate development of human retinal lineage differentiation.
Authors
- Sumiko Watanabe (ORCID: https://orcid.org/0000-0003-4497-5750)
- Hiroshi Kuribayashi
- Akira Murakami (ORCID: https://orcid.org/0000-0002-0022-2514)
- Takeshi Kawamura (ORCID: https://orcid.org/0000-0003-1613-6968)
- Toshiro Iwagawa (ORCID: https://orcid.org/0000-0003-1600-7795)
- Yutaka Suzuki
Institutions
- Juntendo University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1167/iovs.65.12.37
- Citations
- 3
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Japan Society for the Promotion of Science