Roflumilast Attenuates Microglial Senescence and Retinal Inflammatory Neurodegeneration Post Retinal Ischemia Reperfusion Injury Through Inhibiting NLRP3 Inflammasome
Roflu exerts neuroprotective effects by mitigating microglial senescence and inflammation via inhibition of the NLRP3 inflammasome in RIR injury. These findings suggest that Roflu may serve as a promising therapeutic strategy for retinal diseases associated with ischemic injury by targeting microglial senescence.
Authors
- Ying Wu (ORCID: https://orcid.org/0000-0003-2274-9357)
- Chunlian Ou
- Ying Xu (ORCID: https://orcid.org/0000-0002-9987-2057)
- Qiong Liu (ORCID: https://orcid.org/0000-0002-8950-6133)
- Hongyang Zhang (ORCID: https://orcid.org/0000-0002-1289-8327)
- Jing Wu (ORCID: https://orcid.org/0000-0001-9861-4323)
- Jing Wen (ORCID: https://orcid.org/0000-0001-6980-9105)
- Yi‐Wei Lin
- Naiyuan Zhang
- Jing Xu (ORCID: https://orcid.org/0000-0002-8000-2510)
Institutions
- Jinan University (CN)
- Nanfang Hospital (CN)
- Taizhou Central Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1167/iovs.65.12.38
- Citations
- 8
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.87