Adipose-derived mesenchymal stem cells inhibit hepatic stellate cells activation to alleviate liver fibrosis via Hippo pathway
ADMSCs inhibit HSCs activation by regulating YAP/TAZ, thereby promoting functional recovery after liver fibrosis. These findings lay a foundation for further investigation into the precise mechanism by which ADMSCs alleviate liver fibrosis.
Authors
- Haocheng Huang (ORCID: https://orcid.org/0000-0002-9782-203X)
- Shouchao Jin (ORCID: https://orcid.org/0009-0009-8077-7349)
- Guangneng Peng (ORCID: https://orcid.org/0000-0002-9898-5754)
- Hongchuan Deng
- Ziyao Zhou (ORCID: https://orcid.org/0000-0002-5484-5442)
- Dechun Chen (ORCID: https://orcid.org/0000-0002-4339-3778)
- Yuting Yang (ORCID: https://orcid.org/0000-0002-1064-688X)
- Haifeng Liu (ORCID: https://orcid.org/0000-0002-7495-9332)
- Yifan Liu (ORCID: https://orcid.org/0000-0003-3123-8903)
- Xinmiao Wang (ORCID: https://orcid.org/0000-0002-1791-3258)
- Zhijun Zhong (ORCID: https://orcid.org/0009-0003-1071-7160)
Institutions
- Sichuan Agricultural University (CN)
- Sichuan Provincial Architectural Design and Research Institute (China) (CN)
- Southwest Minzu University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1186/s13287-024-03988-7
- Citations
- 7
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China
- Natural Science Foundation of Sichuan Province