Synergy of prediction rule and total synthesis in solving the stereochemical puzzle of eucalactam B
The absolute configurations of the fungal-derived reduced polyketide eucalactam B were initially predicted using the “Biochemistry-based rule” and later confirmed through its first successful total synthesis.
Authors
- Chenqi Wang
- Junyang Liu (ORCID: https://orcid.org/0000-0002-7252-1900)
- Ye Tao (ORCID: https://orcid.org/0000-0002-8075-7323)
Institutions
- Peking University (CN)
- Wuyi University (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1039/d4qo01777c
- Citations
- 1
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.60