ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation
Our findings underscore the hepatoprotective effect of ECM1, which interferes with mediators of LTGF-β1 activation, suggesting ECM1 or its representative peptide as potential antifibrotic therapies in CLD.
Authors
- Roman Liebe (ORCID: https://orcid.org/0000-0002-3199-5595)
- Natalie J. Török (ORCID: https://orcid.org/0000-0001-8074-7048)
- Frederik Link (ORCID: https://orcid.org/0000-0002-8384-705X)
- Dirk Drasdo (ORCID: https://orcid.org/0000-0002-9995-5987)
- Huiguo Ding (ORCID: https://orcid.org/0000-0002-8716-4926)
- Peter ten Dijke (ORCID: https://orcid.org/0000-0002-7234-342X)
- Zeribe C. Nwosu (ORCID: https://orcid.org/0000-0003-1641-2045)
- Chunfang Gao (ORCID: https://orcid.org/0000-0002-4891-2944)
- Weiguo Fan (ORCID: https://orcid.org/0000-0002-2382-5473)
- Stefan Munker (ORCID: https://orcid.org/0000-0002-1305-162X)
- Steven Dooley (ORCID: https://orcid.org/0000-0002-4840-6240)
- Sai Wang (ORCID: https://orcid.org/0000-0002-9731-3948)
- Jieling Zhao
- Seddik Hammad (ORCID: https://orcid.org/0000-0003-0571-4208)
- Hui Liu (ORCID: https://orcid.org/0000-0003-3773-174X)
- Shanshan Wang (ORCID: https://orcid.org/0000-0003-3881-0087)
- Yujia Li (ORCID: https://orcid.org/0000-0002-1024-9243)
- Chen Shao (ORCID: https://orcid.org/0000-0002-6818-6660)
- Yao Ye (ORCID: https://orcid.org/0000-0002-2187-0211)
- Chenjun Huang
- Matthias PA Ebert
- Honglei Weng
- Bing Sun (ORCID: https://orcid.org/0009-0000-1856-2704)
Institutions
- Institut national de recherche en sciences et technologies du numérique (FR)
- Capital Medical University (CN)
- Chinese Academy of Sciences (CN)
- TU Dortmund University (DE)
- Cornell University (US)
- Heidelberg University (DE)
- Leiden University Medical Center (NL)
- University Hospital Heidelberg (DE)
- LMU Klinikum (DE)
- Shanghai University of Traditional Chinese Medicine (CN)
- Oncode Institute (NL)
- Center for Excellence in Molecular Cell Science (CN)
- Centre Inria de Saclay (FR)
- Yueyang Hospital (CN)
- European Molecular Biology Laboratory (DE)
- Beijing YouAn Hospital (CN)
- University Medical Centre Mannheim (DE)
- Leibniz Research Centre for Working Environment and Human Factors (DE)
- Ludwig-Maximilians-Universität München (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Stanford University (US)
Publication Details
- Journal
- Gut
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1136/gutjnl-2024-333213
- Citations
- 38
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 14.04
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung