Evaluation of Effective Half-Life and Its Impact on Time to Steady State for Oral MeltDose Tacrolimus (LCPT) in De Novo Kidney Transplant Recipients
Consistent with its prolonged release of tacrolimus, LCPT demonstrated a higher accumulation ratio and a longer t 1/2eff compared with IR-Tac. These findings underscore the pharmacokinetic differences between different drug formulations of the same moiety and may help inform dose adjustments for LCPT in kidney transplantation.
Authors
- Brian M. Masters (ORCID: https://orcid.org/0000-0003-1841-5135)
- Kelly A. Birdwell (ORCID: https://orcid.org/0000-0002-7996-3947)
- Arin Jantz (ORCID: https://orcid.org/0000-0003-2146-2880)
- Diane M. Cibrik
- Raman Venkataramanan
- Jeremiah D. Momper (ORCID: https://orcid.org/0000-0002-3154-6685)
- Samir J. Patel (ORCID: https://orcid.org/0000-0001-6316-9514)
- Tk Nguyen
Institutions
- University of Kansas (US)
- Henry Ford Health System (US)
- University of Pittsburgh (US)
- University of California San Diego (US)
- The Carolinas Center (US)
- University of Montana (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1097/ftd.0000000000001270
- Citations
- 3
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52