ROR1 facilitates glioblastoma growth via stabilizing GRB2 to promote c-Fos expression in glioma stem cells
ROR1 plays essential roles in GSCs maintenance through binding to GRB2 and activation of ERK/c-Fos signaling, which highlights the therapeutic potential of targeting the ROR1-GRB2-c-Fos axis.
Authors
- Lidong Cheng
- Xiaoyu Ma (ORCID: https://orcid.org/0000-0001-8144-0232)
- Suojun Zhang
- Hailong Mi
- Xingjiang Yu (ORCID: https://orcid.org/0000-0001-5630-3076)
- Hongtao Zhu (ORCID: https://orcid.org/0000-0002-3747-6489)
- Zhiye Chen (ORCID: https://orcid.org/0000-0002-5463-8013)
- Dan Liu (ORCID: https://orcid.org/0000-0002-2866-4226)
- Yang Zhang (ORCID: https://orcid.org/0000-0002-5992-5310)
- Jun Li (ORCID: https://orcid.org/0000-0001-7218-429X)
- Ran Li (ORCID: https://orcid.org/0000-0002-3636-3714)
- Kai Shu (ORCID: https://orcid.org/0000-0001-7789-125X)
- Heng Fan
Institutions
- Central Hospital of Wuhan (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1093/neuonc/noae224
- Citations
- 8
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.87