Associations Between Paramagnetic Rim Lesion Evolution and Clinical and Radiologic Disease Progression in Persons With Multiple Sclerosis
Our results show that resolution of existing PRLs and lack of new PRLs are associated with improved clinical outcomes. These findings further motivate the need for novel therapies targeting microglia-mediated brain inflammation and adoption of clinical strategies to prevent appearance of new PRL.
Authors
- Jack A. Reeves (ORCID: https://orcid.org/0009-0002-4079-5664)
- Gregory E. Wilding (ORCID: https://orcid.org/0000-0001-5569-9363)
- Ferdinand Schweser (ORCID: https://orcid.org/0000-0003-0399-9211)
- Michael G. Dwyer (ORCID: https://orcid.org/0000-0003-4684-4658)
- Maryam Mohebbi (ORCID: https://orcid.org/0000-0003-2326-6074)
- Dejan Jakimovski (ORCID: https://orcid.org/0000-0001-7114-4958)
- Alexander Bartnik (ORCID: https://orcid.org/0000-0001-9676-7377)
- Niels Bergsland (ORCID: https://orcid.org/0000-0002-7792-0433)
- Bianca Weinstock‐Guttman (ORCID: https://orcid.org/0000-0001-6732-151X)
- Fahad Salman (ORCID: https://orcid.org/0009-0000-3873-2301)
- Robert Zivadinov (ORCID: https://orcid.org/0000-0002-7799-1485)
Institutions
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Neurology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1212/wnl.0000000000210004
- Citations
- 24
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 10.20