The Bidirectional Effects of Periodontal Disease and Oral Dysbiosis on Gut Inflammation in Inflammatory Bowel Disease
Our study suggests that patients with aIBD have severer periodontal disorders and higher relative abundances of putative 'pro-inflammatory' microbiota in their oral cavity, despite normal oral hygiene behaviors. Our data are consistent with the potential presence of an oral-gut inflammatory axis that could trigger IBD flare-ups in at-risk patients. Routine dental health assessments in all IBD patients should be encouraged as part of the health maintenance of IBD and as a potential strategy to decrease the risk of IBD flares.
Authors
- Ali Keshavarzian (ORCID: https://orcid.org/0000-0002-7969-3369)
- Kristi Lawrence (ORCID: https://orcid.org/0000-0002-9392-3992)
- Joel Schwartz (ORCID: https://orcid.org/0000-0002-2557-150X)
- Stefan J. Green (ORCID: https://orcid.org/0000-0003-2781-359X)
- Darbaz Adnan (ORCID: https://orcid.org/0000-0002-8583-8966)
- Zoë Post (ORCID: https://orcid.org/0000-0002-3397-507X)
- Ankur Naqib (ORCID: https://orcid.org/0000-0003-0832-5646)
- Netanel Zilberstein (ORCID: https://orcid.org/0000-0001-5409-8654)
- Garth Swanson (ORCID: https://orcid.org/0000-0001-5822-6924)
- Robin M. Voigt (ORCID: https://orcid.org/0000-0002-8010-0786)
- Phillip A. Engen (ORCID: https://orcid.org/0000-0002-5276-5174)
- Julian Alutto
- Lijuan Zhang (ORCID: https://orcid.org/0000-0001-8013-9448)
- Maliha Shaikh
Institutions
- Rush University Medical Center (US)
- University of Illinois Chicago (US)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1093/ecco-jcc/jjae162
- Citations
- 11
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- National Institute on Alcohol Abuse and Alcoholism
- National Center for Advancing Translational Sciences