High expression of PLA2G2A in fibroblasts plays a crucial role in the early progression of carotid atherosclerosis
Our study discovered and validated that PLA2G2A is highly expressed by vascular fibroblasts and promotes plaque progression through the activation of macrophage complement and coagulation cascade pathways in the early-stage of CA.
Authors
- Xuyang Liu
- Shuang Cao (ORCID: https://orcid.org/0000-0002-1855-3426)
- C. Liu (ORCID: https://orcid.org/0000-0001-5451-8305)
- Yuming Xu (ORCID: https://orcid.org/0000-0003-2689-9897)
- Feng Zhang (ORCID: https://orcid.org/0000-0002-6103-1498)
- Li Shen (ORCID: https://orcid.org/0000-0002-5696-2191)
- Guofeng Ren (ORCID: https://orcid.org/0000-0002-8422-9608)
- Xin Wang (ORCID: https://orcid.org/0000-0003-1059-9953)
- Jiawei Zhao (ORCID: https://orcid.org/0000-0002-5892-7728)
- Zuo Li Xia
Institutions
- Zhengzhou University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1186/s12967-024-05679-6
- Citations
- 8
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.95