Engineered melatonin-pretreated plasma exosomes repair traumatic spinal cord injury by regulating miR-138-5p/SOX4 axis mediated microglia polarization
This study highlights that melatonin enhances the anti-inflammatory function of Exos through delivery of miR-138-5p. Activation of miR-138-5p/SOX4 axis by engineered melatonin-pretreated plasma exosomes may be a potential target for SCI treatment.
Authors
- Yongxiang Wang (ORCID: https://orcid.org/0000-0003-3763-7411)
- B. H. Wan
- Hao Chen (ORCID: https://orcid.org/0000-0003-0393-723X)
- Jian Yin (ORCID: https://orcid.org/0000-0002-4874-3810)
- Jijun Huang (ORCID: https://orcid.org/0000-0002-5520-193X)
- Aoying Li
- Xinmin Feng (ORCID: https://orcid.org/0000-0001-9287-858X)
- Pingchuan Wang (ORCID: https://orcid.org/0000-0002-2376-2433)
- Shengfei Zhang
- Zhiqiang Zhang (ORCID: https://orcid.org/0000-0002-3855-8101)
- Hui-Hui Sun
- Liang Zhang (ORCID: https://orcid.org/0000-0003-2369-3578)
- Jun Cai (ORCID: https://orcid.org/0000-0001-7667-3357)
- Junxiang Yin (ORCID: https://orcid.org/0000-0002-9675-3802)
- Xizhao Chen (ORCID: https://orcid.org/0000-0002-0528-3375)
- Wu Xiong (ORCID: https://orcid.org/0000-0001-5799-9407)
- Yaqing Yang
Institutions
- Xuzhou Medical College (CN)
- Jiangsu Vocational College of Medicine (CN)
- Northern Jiangsu People's Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Jiangning Hospital (CN)
- Yangzhou University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1016/j.jot.2024.09.007
- Citations
- 11
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.57