Effect of ayurveda-based panchakarma and lifestyle modification on global longitudinal strain in cardiac disorder patients

Background: The present sought to study the change in global longitudinal strain (GLS) after 90 days in known cases of cardiac disorders with Ayurveda based Panchakarma and lifestyle modification. Methods: A retrospective, observational, single-centre study was conducted from July 2021 to April 2022 in Maharashtra, India. Patients aged 18 years and above, diagnosed with inducible ischemia on stress test who underwent the ischemia reversal program (IRP) included in this study. Follow-up was conducted at 90 days. Day 1 and day 90 data were compared. Results: A total of 32 patients were assessed. Anthropometric variables such as weight (day1: 68.31±12.40 kg and day 90: 63.82±10.93 kg, p=0.00) and abdominal girth (day 1: 93.56±9.60 cm and day 90: 88.22±6.19 cm, p=0.00) improved at the 90-day follow-up. The lipid profile also improved for variables such as high-density lipoprotein (day 1: 27.66±2.69 mmol/l and day 90: 31.94±2.69 mmol/l, p=0.00), low-density lipoprotein (day 1: 146.88 ± 44.68 mmol/l and day 90: 102.00±9.10 mmol/l, p=0.00), and triglycerides (day 1: 206.03±43.41 mmol/l and day 90: 157.53±35.70 mmol/l, p=0.00). Vo2 max changed from 16.93 ± 7.87 ml/kg/min to 30.83±3.76 ml/kg/min, p=0.00). GLS improved from -14.08±3.79 to -16.35±3.26. Conclusion: Panchakarma therapy and lifestyle modifications help in improving global longitudinal strain, reducing symptoms of chest pain, breathlessness, dyspnea on exertion, improved V02 peak and improved weight loss and ejection fraction.