Progression trajectories from prodromal to overt synucleinopathies: a longitudinal, multicentric brain [18F]FDG-PET study
The phenoconversion trajectory from idiopathic/isolated Rapid eye movement (REM) sleep behavior disorder (iRBD) towards either Parkinson's Disease (PD) or Dementia with Lewy Bodies (DLB) is currently uncertain. We investigated the capability of baseline brain [<sup>18</sup>F]FDG-PET in differentiating between iRBD patients eventually phenoconverting to PD or DLB, by deriving the denovoPDRBD-related pattern (denovoPDRBD-RP) from 32 de novo PD patients; and the denovoDLBRBD-RP from 30 de novo DLB patients, both with evidence of RBD at diagnosis. To explore [<sup>18</sup>F]FDG-PET phenoconversion trajectories prediction power, we applied these two patterns on a group of 115 iRBD patients followed longitudinally. At follow-up (25.6 ± 17.2 months), 42 iRBD patients progressed through overt alpha-synucleinopathy (21 iRBD-PD and 21 iRBD-DLB converters), while 73 patients remained stable at the last follow-up visit (43.2 ± 27.6 months). At survival analysis, both patterns were significantly associated with the phenoconversion trajectories. Brain [<sup>18</sup>F]FDG-PET is a promising biomarker to study progression trajectories in the alpha-synucleinopathy continuum.
Authors
- Yu Kyeong Kim (ORCID: https://orcid.org/0000-0002-3282-822X)
- Mariana Fernandes (ORCID: https://orcid.org/0000-0002-7005-2805)
- Matteo Bauckneht (ORCID: https://orcid.org/0000-0002-1937-9116)
- Francesco Famà (ORCID: https://orcid.org/0000-0002-9084-9037)
- Pietro Mattioli (ORCID: https://orcid.org/0000-0003-2563-5830)
- Andrea Brugnolo (ORCID: https://orcid.org/0000-0002-5708-0940)
- Matteo Spanetta
- Ryul Kim (ORCID: https://orcid.org/0000-0002-8754-9180)
- Federico Massa (ORCID: https://orcid.org/0000-0001-5667-204X)
- Agostino Chiaravalloti (ORCID: https://orcid.org/0000-0002-8017-8858)
- Matteo Pardini (ORCID: https://orcid.org/0000-0002-4740-1982)
- Jung Hwan Shin (ORCID: https://orcid.org/0000-0003-4182-3612)
- Dario Arnaldi (ORCID: https://orcid.org/0000-0001-6823-6069)
- Silvia Daniela Morbelli (ORCID: https://orcid.org/0000-0002-7833-6095)
- Beatrice Orso (ORCID: https://orcid.org/0000-0001-9983-7940)
- Claudio Liguori (ORCID: https://orcid.org/0000-0003-2845-1332)
- Fabio Placidi (ORCID: https://orcid.org/0000-0002-5214-5581)
- Jee‐Young Lee (ORCID: https://orcid.org/0000-0002-9120-2075)
- Heejung Kim (ORCID: https://orcid.org/0000-0001-6215-5639)
- Eun Jin Yoon (ORCID: https://orcid.org/0000-0003-4547-0420)
Institutions
- University of Rome Tor Vergata (IT)
- Seoul National University (KR)
- Seoul Metropolitan Government (KR)
- Istituto Neurologico Mediterraneo (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Ospedale Santa Maria (IT)
- Ospedale Policlinico San Martino (IT)
- Inha University Hospital (KR)
- University of Turin (IT)
- University of Genoa (IT)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1038/s41531-024-00813-z
- Citations
- 10
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.69
Funders
- European Commission
- National Research Foundation
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea