Epigenetic associations with kidney disease in individuals of African ancestry with <i>APOL1</i> high-risk genotypes and HIV
We report several novel as well as previously reported epigenetic associations with CKD and eGFR in individuals with HIV having APOL1 high-risk genotypes. Further investigation of pathways linking DNA methylation to APOL1 nephropathies is warranted.
Authors
- Kate Bramham (ORCID: https://orcid.org/0000-0002-6272-7921)
- Cheryl Ann Winkler (ORCID: https://orcid.org/0000-0001-5552-0917)
- John Booth (ORCID: https://orcid.org/0000-0003-4357-1324)
- Yan V. Sun (ORCID: https://orcid.org/0000-0002-2838-1824)
- Pascal Schlosser (ORCID: https://orcid.org/0000-0002-8460-0462)
- Claire C. Sharpe (ORCID: https://orcid.org/0000-0003-1704-8492)
- Frank A. Post (ORCID: https://orcid.org/0000-0002-2844-1612)
- Franziska Grundner-Culemann (ORCID: https://orcid.org/0000-0001-9649-281X)
- Rachel Hung (ORCID: https://orcid.org/0000-0002-4117-6921)
- Vincent C. Marconi (ORCID: https://orcid.org/0000-0001-8409-4689)
- Jordana T. Bell (ORCID: https://orcid.org/0000-0002-3858-5986)
- Alexander Teumer (ORCID: https://orcid.org/0000-0002-8309-094X)
- Ricardo Costeira (ORCID: https://orcid.org/0000-0002-8316-5219)
- Junyu Chen (ORCID: https://orcid.org/0000-0001-9659-0225)
Institutions
- Johns Hopkins University (US)
- Medical University of Białystok (PL)
- Emory University (US)
- University of Freiburg (DE)
- King's College London (GB)
- Barts Health NHS Trust (GB)
- Universitätsmedizin Greifswald (DE)
- University Medical Center Freiburg (DE)
- King's College Hospital NHS Foundation Trust (GB)
- German Centre for Cardiovascular Research (DE)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (US)
- Atlanta VA Health Care System (US)
- Center for Cancer Research (US)
- King's College Hospital (GB)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1093/ndt/gfae237
- Citations
- 2
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.68
Funders
- U.S. Department of Health and Human Services
- International AIDS Society
- National Institutes of Health
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- National Cancer Institute