Effects of invigorating-spleen and anticancer prescription on extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway in colon cancer mice model
ISAP has a potential inhibiting effect on transplanted tumor in mice, and could maintain the general conditions, physical strength and body weight of mice. The expression levels of <i>RAS</i>, <i>p-ERK</i>, <i>MMP2</i> and <i>c-myc</i> were also decreased to a certain extent. By inhibiting the expression of upstream proteins, the expression levels of downstream proteins in ERK/MAPK signaling pathway were significantly decreased. Therefore, it can be concluded that ISAP may exert an anti-tumor effect by blocking the ERK/MAPK signaling pathway and inhibiting the expression of MMP2 and c-myc proteins.
Authors
- Xiuxiu Ren (ORCID: https://orcid.org/0000-0002-4477-2120)
- Hai-Long Yue
- Jing Wang (ORCID: https://orcid.org/0000-0003-4343-2527)
- Zheng Li (ORCID: https://orcid.org/0000-0002-6141-4990)
- Wei Wang (ORCID: https://orcid.org/0009-0006-4755-1194)
Institutions
- Liaoning University (CN)
- Liaoning University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (CN)
- Liaoning Cancer Hospital & Institute (CN)
- China Medical University (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Oncology
- Published
- 2024-10-25
- DOI
- https://doi.org/10.4251/wjgo.v16.i11.4468
- Citations
- 1
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Liaoning University
- Liaoning University of Traditional Chinese Medicine
- Department of Science and Technology of Liaoning Province