<i>BIRC3</i> induces the phosphoinositide 3-kinase-Akt pathway activation to promote trastuzumab resistance in human epidermal growth factor receptor 2-positive gastric cancer
This study revealed a robust association between high <i>BIRC3</i> expression and an unfavorable prognosis in patients with HER2-positive gastric cancer. Thus, the high expression of <i>BIRC3</i> stimulated PI3K-AKT phosphorylation and activation, stimulating the proliferation of HER2-positive tumor cells and suppressing apoptosis, ultimately leading to trastuzumab resistance.
Authors
- Pei‐Yao Wang
- Zhao‐Xiong Zhang (ORCID: https://orcid.org/0000-0002-0073-5416)
- Weihua Fu (ORCID: https://orcid.org/0000-0003-2576-865X)
- Hao-Yu He
- Peng-Yu Chen (ORCID: https://orcid.org/0000-0002-5577-5546)
- Xin Liu (ORCID: https://orcid.org/0000-0001-8228-3689)
- Bang Liu (ORCID: https://orcid.org/0000-0003-3045-2019)
- Li Lü (ORCID: https://orcid.org/0000-0003-0915-1588)
- Shuliang Li (ORCID: https://orcid.org/0000-0002-2948-9124)
- Yanwen Jia (ORCID: https://orcid.org/0000-0003-3545-9869)
Institutions
- Tianjin Medical University General Hospital (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Oncology
- Published
- 2024-10-25
- DOI
- https://doi.org/10.4251/wjgo.v16.i11.4436
- Citations
- 3
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.70