Factors contributing to variability in neurocognitive performance before glioma neurosurgery
Glioma patients frequently exhibit objective and subjective impairments prior to treatment. Both tumor- and self-reported factors were identified as predictors of performance, after correcting for estimated premorbid IQ. Nevertheless, more than 41.7% of the variance in cognitive performance remained unexplained, indicating a substantial role for additional, as yet unaccounted for, clinical factors. Notable disparity between objective and subjective cognitive impairment status re-emphasizes the importance of assessing both domains to ascertain a patient's overall functioning in the context of treatment outcomes.
Authors
- Susan Isabel Honeyman (ORCID: https://orcid.org/0000-0002-5117-9405)
- Juan F. Mier-García (ORCID: https://orcid.org/0000-0003-2221-7916)
- Natalie Voets (ORCID: https://orcid.org/0000-0001-8078-4471)
- Puneet Plaha (ORCID: https://orcid.org/0000-0003-3103-6359)
- Izabelle Lövgren (ORCID: https://orcid.org/0000-0001-9574-2477)
- Richard Stacey (ORCID: https://orcid.org/0000-0002-0777-4194)
- Vasileios Apostolopoulos (ORCID: https://orcid.org/0000-0001-9719-4769)
- Claire L. Isaac
Institutions
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- Wellcome Centre for Integrative Neuroimaging (GB)
- Oxford University Hospitals NHS Trust (GB)
Publication Details
- Journal
- Neuro-Oncology Practice
- Published
- 2024-10-20
- DOI
- https://doi.org/10.1093/nop/npae106
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- University of Oxford
- Oxford University Hospitals NHS Foundation Trust