Quercetin inhibits mitophagy-mediated apoptosis and inflammatory response by targeting the PPARγ/PGC-1α/NF-κB axis to improve acute liver failure
In short, our results provide the first evidence that QUE improves acute liver failure by promoting mitophagy through regulating the PPARγ/PGC-1α/NF-κB axis and inhibiting apoptosis and inflammatory responses mediated by mitochondrial dysfunction, which provides evidence for the potential of QUE in the treatment of ALF.
Authors
- Long‐Jun Wu (ORCID: https://orcid.org/0000-0001-8019-3380)
- Ligang Luo (ORCID: https://orcid.org/0000-0001-8208-8760)
- Qingxiu Zhang (ORCID: https://orcid.org/0000-0001-5285-2908)
- Huan Wu (ORCID: https://orcid.org/0000-0003-2752-8035)
- Bao-fang Zhang
- Yeting Wu
- Haiyang Li (ORCID: https://orcid.org/0000-0002-9506-0430)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1016/j.intimp.2024.113444
- Citations
- 13
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 3.04