Negative pressure pulmonary edema and angioedema: a fatal correlation

Negative pressure pulmonary edema (NPPE), a non-cardiogenic pulmonary edema resulting from acute or chronic upper airway obstruction, remains a significant challenge in critical care settings due to the morbidity and mortality associated with undiagnosed cases. The most accepted pathophysiology involves the high inspiratory pressure required to counteract the upper airway obstruction, which leads to progressive negative intrapleural pressure. This results in increased pulmonary microvascular pressure, causing alveolar flooding. Among reported cases, laryngospasm in the postoperative period is the most common cause of NPPE. Management involves securing the airway and providing positive pressure ventilation. However, prevention and treatment remain subjects of further research.