Eight induced pluripotent stem cell lines (iPSCs) derived from two patients with Leukocyte adhesion deficiency Type I (LAD I) with mutations in the ITGB2 gene
Leukocyte Adhesion Deficiency Type I (LAD I) is a rare inborn error of immunity caused by mutations in the ITGB2 gene coding for β2-integrin CD18 on the surface of leukocytes. Affected patients display severe clinical manifestations with life threatening infections and inflammatory complications due to an impaired ability of leukocytes to transmigrate from the blood vessel to the tissue. Here we describe the generation of eight induced pluripotent stem cell lines from two patients with LAD I and mutations in the ITGB2 gene. With this project we contribute patient individualized cell lines for explorative research in a rare disease.
Authors
- Ute Modlich (ORCID: https://orcid.org/0000-0001-8018-4118)
- Manfred Hoenig (ORCID: https://orcid.org/0000-0001-9165-1690)
- Hermann Kreyenberg (ORCID: https://orcid.org/0000-0003-3575-9175)
- Melanie Bremm
- Sabine Huenecke
- Peter Bader (ORCID: https://orcid.org/0000-0003-4554-0265)
- Eva‐Maria Jacobsen (ORCID: https://orcid.org/0000-0003-4750-0136)
- Shahrzad Bakhtiar (ORCID: https://orcid.org/0000-0002-9898-1542)
- Franziska Schenk (ORCID: https://orcid.org/0000-0001-9530-9403)
- Renate König (ORCID: https://orcid.org/0000-0003-4882-9179)
- Stefan Zahn (ORCID: https://orcid.org/0000-0002-4858-0687)
- Marcel G. E. Rommel (ORCID: https://orcid.org/0000-0003-4861-3175)
- Klaus Schwarz (ORCID: https://orcid.org/0000-0003-3178-5990)
- Nina V. Fuchs (ORCID: https://orcid.org/0000-0003-4175-0740)
- Zyrafete Kuçi
- Julia Fekadu-Siebald
Institutions
- Goethe University Frankfurt (DE)
- University of California, Santa Cruz (US)
- German Red Cross (DE)
- Swiss Institute for Regenerative Medicine (CH)
- Paul Ehrlich Institut (DE)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1016/j.scr.2024.103598
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Goethe-Universität Frankfurt am Main