Dihydrokoumine, a dual-target analgesic with reduced side effects isolated from a traditional Chinese medicine
A MOR partial agonist/M3R antagonist analgesic with reduced side effects was isolated from a traditional Chinese medicine. This study bestows dihydrokoumine as a new dual-target analgesic and as a potential lead compound in long-term pain management.
Authors
- Jixia Wang (ORCID: https://orcid.org/0000-0002-4971-0797)
- Dian Liu
- Yaopeng Zhao (ORCID: https://orcid.org/0000-0003-2100-6113)
- Liangliang Zhou (ORCID: https://orcid.org/0000-0001-6148-8212)
- Han Zhou (ORCID: https://orcid.org/0009-0008-9595-219X)
- Cuiyan Cao (ORCID: https://orcid.org/0000-0003-1764-9351)
- Tao Hou (ORCID: https://orcid.org/0000-0002-7567-2800)
- Yan Zhang (ORCID: https://orcid.org/0000-0003-0244-218X)
- Yanfang Liu (ORCID: https://orcid.org/0000-0003-2886-6554)
- Xinmiao Liang
Institutions
- Dalian Institute of Chemical Physics (CN)
- Shanghai Jiao Tong University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1016/j.jare.2024.10.011
- Citations
- 1
- Primary Topic
- Chemical synthesis and alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- National Natural Science Foundation of China
- Dalian Institute of Chemical Physics