Cerebral and myocardial kinetics of [11C]acetoacetate and [11C]β-hydroxybutyrate: A comparative crossover study in healthy rats
[<sup>11</sup>C]acetoacetate and [<sup>11</sup>C]β-hydroxybutyrate can be used interchangeably for measuring global CMR in healthy rats but differ in certain cerebral and myocardial kinetics. Whether these findings are generalizable to pathological conditions warrants further studies to explore the kinetics of these tracers in disease models.
Authors
- Thien Vinh Luong (ORCID: https://orcid.org/0000-0002-5772-4494)
- Lars Christian Gormsen (ORCID: https://orcid.org/0000-0002-0144-1305)
- Esben Søndergaard (ORCID: https://orcid.org/0000-0001-8041-6994)
- Mette Louise Gram Kjærulff
- Étienne Croteau (ORCID: https://orcid.org/0000-0002-4971-6443)
- Niels Møller (ORCID: https://orcid.org/0000-0001-5627-7322)
- Valérie St‐Pierre
- Stephen C. Cunnane (ORCID: https://orcid.org/0000-0003-4003-9762)
- Sébastien Tremblay (ORCID: https://orcid.org/0000-0002-1347-6329)
- Richard Gabriel
Institutions
- Université de Sherbrooke (CA)
- Centre Hospitalier Universitaire de Sherbrooke (CA)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Nuclear Medicine and Biology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1016/j.nucmedbio.2024.108967
- Citations
- 2
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- Aarhus Universitet
- Université de Sherbrooke
- Novo Nordisk
- Novo Nordisk Fonden
- Diabetesforeningen
- Sundhedsvidenskabelige Fakultet, Aarhus Universitet