Tangeretin inhibits airway inflammatory responses by reducing early growth response 1 (EGR1) expression in mice exposed to cigarette smoke and lipopolysaccharide
Comprehensively, tangeretin inhibits the lung inflammatory response associated with COPD by reducing EGR1 expression in PMA-induced human epithelial cells and in a CS/LPS-stimulated mouse model. This study shows that tangeretin has anti-COPD properties and can be a promising alternative (or complementary) treatment for inflammatory lung disease.
Authors
- Yu Na Song
- Myung-Ji Kang (ORCID: https://orcid.org/0000-0003-0326-2156)
- Su Ui Lee (ORCID: https://orcid.org/0000-0002-6455-5414)
- Eun Sol Oh (ORCID: https://orcid.org/0000-0002-0313-4747)
- Sung-Tae Hong (ORCID: https://orcid.org/0000-0001-5981-4859)
- Mun-Ock Kim (ORCID: https://orcid.org/0000-0003-3722-5724)
- Hyunju Ro (ORCID: https://orcid.org/0000-0002-0829-9639)
- Jae‐Won Lee (ORCID: https://orcid.org/0000-0003-0438-6732)
- Juhyun Lee (ORCID: https://orcid.org/0000-0001-8623-0744)
- Ro Woon Lee
- Seok Han Yun
Institutions
- Chungnam National University (KR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
Publication Details
- Journal
- Heliyon
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e39797
- Citations
- 6
- Primary Topic
- Bioactive Compounds in Plants
- Type
- article
- Field-Weighted Citation Impact
- 3.60
Funders
- National Research Foundation
- Chungnam National University
- Korea Research Institute of Bioscience and Biotechnology
- National Research Foundation of Korea
- Asan Institute for Life Sciences, Asan Medical Center
- Ministry of Science and ICT, South Korea