Association Between TTV Viremia, Chronic Inflammation, and Ischemic Heart Disease Risk: Insights From MARK-AGE and Report-Age Projects

The implication of Torquetenovirus (TTV) in ischemic heart disease (IHD) has not been thoroughly explored. This study investigated the association between TTV viremia, pro-inflammatory cytokines, and IHD risk in an aging population. This cross-sectional study included 900 non-IHD subjects and 86 individuals with IHD (aged 55-75 years) selected from the MARK-AGE project. Results were verified in another independent Report-Age cohort, including 94 inpatients with chronic IHD and 111 inpatients with non-IHD (aged 65-96 years). Multivariable logistic regression in the MARK-AGE cohort revealed that male sex, TTV viremia ≥4log, Cu/Zn ratio, diabetes, hypertension, and smoking were significant IHD predictors. Notably, TTV viremia ≥4log independently increased the IHD risk (odds ratio [OR]: 2.51, 95% confidence interval [CI]: 1.42-4.43), confirmed in the Report-Age cohort (OR: 4.90, 95% CI: 2.32-10.39). In a RASIG subgroup, individuals with TTV viremia ≥4 log, both with and without IHD, exhibited increased plasma pro-inflammatory cytokine levels (IFN-γ, IL-1β, IL-6, IL-10, IL-12p70, TNF-α) compared to those with TTV viremia <4 log. No significant difference in cytokine production was observed between IHD patients and non-IHD with TTV viremia ≥4 log. A positive correlation between TTV viremia and DNA methylation estimator of leukocyte telomere length was observed in Report-Age patients. Additionally, IHD Report-Age patients with TTV viremia ≥4 log displayed higher NLR and SIRI index than those with TTV viremia <4 log. In conclusion, a high TTV viremia is associated with an elevated IHD risk in the older population, potentially arising from an augmented pro-inflammatory response and immunosenescence.

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Publication Details

Journal
The Journals of Gerontology Series A
Published
2024-10-24
DOI
https://doi.org/10.1093/gerona/glae228
Citations
7
Primary Topic
Animal Virus Infections Studies
Type
article
Field-Weighted Citation Impact
2.39

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article

Association Between TTV Viremia, Chronic Inflammation, and Ischemic Heart Disease Risk: Insights From MARK-AGE and Report-Age Projects

Anna Rita Bonfigli, Claudia Minosse, Mirko Di Rosa, Paolo Grossi et al.
7 citations
The Journals of Gerontology Series A
Animal Virus Infections Studies
2.39
article

Association Between TTV Viremia, Chronic Inflammation, and Ischemic Heart Disease Risk: Insights From MARK-AGE and Report-Age Projects

Anna Rita Bonfigli, Claudia Minosse, Mirko Di Rosa, Paolo Grossi, Fabrizia Lattanzio, Marco Malavolta, Antonio Cherubini, Roberta Galeazzi, Wolfgang Stuetz, Efstathios S. Gonos, Alexander Bürkle, Monia Cecati, Francesco Piacenza, Nicasio Mancini, Martijn E.T. Dollé, Pietro Giorgio Spezia, Robertina Giacconi, Mikko Hurme, Fabrizio Maggi, Birgit Weinberger, María Moreno Villanueva, Florence Debacq‐Chainiaux, Eugène Jansen, Ewa Sikora, Davide Gentilini, Miriam Capri, P. Eline Slagboom, Federica Novazzi, Francesca Drago Ferrante, Claudio Franceschi, Lucia Mancinelli, Luciano Calzari, Tilman Grune, Mauro Provinciali, Jürgen Bernhardt
article en
7 citations

Abstract

The implication of Torquetenovirus (TTV) in ischemic heart disease (IHD) has not been thoroughly explored. This study investigated the association between TTV viremia, pro-inflammatory cytokines, and IHD risk in an aging population. This cross-sectional study included 900 non-IHD subjects and 86 individuals with IHD (aged 55-75 years) selected from the MARK-AGE project. Results were verified in another independent Report-Age cohort, including 94 inpatients with chronic IHD and 111 inpatients with non-IHD (aged 65-96 years). Multivariable logistic regression in the MARK-AGE cohort revealed that male sex, TTV viremia ≥4log, Cu/Zn ratio, diabetes, hypertension, and smoking were significant IHD predictors. Notably, TTV viremia ≥4log independently increased the IHD risk (odds ratio [OR]: 2.51, 95% confidence interval [CI]: 1.42-4.43), confirmed in the Report-Age cohort (OR: 4.90, 95% CI: 2.32-10.39). In a RASIG subgroup, individuals with TTV viremia ≥4 log, both with and without IHD, exhibited increased plasma pro-inflammatory cytokine levels (IFN-γ, IL-1β, IL-6, IL-10, IL-12p70, TNF-α) compared to those with TTV viremia <4 log. No significant difference in cytokine production was observed between IHD patients and non-IHD with TTV viremia ≥4 log. A positive correlation between TTV viremia and DNA methylation estimator of leukocyte telomere length was observed in Report-Age patients. Additionally, IHD Report-Age patients with TTV viremia ≥4 log displayed higher NLR and SIRI index than those with TTV viremia <4 log. In conclusion, a high TTV viremia is associated with an elevated IHD risk in the older population, potentially arising from an augmented pro-inflammatory response and immunosenescence.

The Journals of Gerontology Series AVol. 79(11)
University of Hohenheim (DE), University of Insubria (IT), Leiden University (NL), Marche Polytechnic University (IT), University of Namur (BE), Tampere University (FI), Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL), University of Konstanz (DE), Universität Innsbruck (AT), University of Pavia (IT), Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani (IT), Mater Research (AU), National Institute for Public Health and the Environment (NL), BioTeSys (Germany) (DE), National Hellenic Research Foundation (GR), IRCCS Istituto Auxologico Italiano (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Istituto Nazionale di Riposo e Cura per Anziani (IT), German Institute of Human Nutrition (DE), Aziende Socio Sanitarie Territoriale dei Sette Laghi, N. I. Lobachevsky State University of Nizhny Novgorod (RU), Center for Excellence in Education (US), University of Bologna (IT), Polish Academy of Sciences (PL)
European Commission
Good health and well-being
Openalex Percentile: Top 12%
Animal Virus Infections Studies
2.39
DOIOpen Access PDFOpenAlex
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