Gut-first Parkinson’s disease is encoded by gut dysbiome
We propose that the dysbiotic gut microbiome (dysbiome) in PD can disrupt a healthy microbiome and Th17 homeostatic immunity in the ileum mucosa, leading to a cascade effect that propagates to the brain, ultimately contributing to PD pathophysiology. Our landmark study has successfully identified new peripheral biomarkers that could be used to develop highly effective strategies to prevent the progression of PD into the brain.
Authors
- Mariana Sant’Anna
- Ana Morgadinho (ORCID: https://orcid.org/0000-0001-6841-251X)
- Emanuel Candeias (ORCID: https://orcid.org/0000-0002-8511-5821)
- Nuno Empadinhas (ORCID: https://orcid.org/0000-0001-8938-7560)
- Ana Maranha (ORCID: https://orcid.org/0000-0001-9005-8377)
- A. Raquel Pereira-Santos (ORCID: https://orcid.org/0000-0002-1595-3360)
- Diogo Reis Carneiro (ORCID: https://orcid.org/0000-0001-8912-4736)
- Pedro Figueiredo (ORCID: https://orcid.org/0000-0001-9872-6341)
- Mario Muñoz (ORCID: https://orcid.org/0000-0001-7354-2888)
- Sandra M. Cardoso (ORCID: https://orcid.org/0000-0002-2199-0555)
- A. Raquel Esteves (ORCID: https://orcid.org/0000-0001-8403-2015)
- Daniela Nunes‐Costa (ORCID: https://orcid.org/0000-0003-3398-9233)
- Igor Tiago (ORCID: https://orcid.org/0000-0002-9301-3585)
- João D. Magalhães (ORCID: https://orcid.org/0000-0003-4890-4167)
- João Lemos (ORCID: https://orcid.org/0000-0002-9128-7064)
- Susana Alarico (ORCID: https://orcid.org/0000-0002-1615-6099)
- Inês Melo-Marques (ORCID: https://orcid.org/0000-0003-2128-296X)
- António E. Abreu (ORCID: https://orcid.org/0009-0009-2363-8131)
- Cristina Januário
Institutions
- Hospitais da Universidade de Coimbra (PT)
- University of Coimbra (PT)
- Universidad de Sevilla (ES)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1186/s13024-024-00766-0
- Citations
- 58
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 21.41
Funders
- Cure Parkinson's Trust
- Instituto Nacional de Ciência e Tecnologia de Ciência Animal