IL-33/ST2 signaling in monocyte-derived macrophages maintains blood-brain barrier integrity and restricts infarctions early after ischemic stroke
Our results demonstrate that early-stage IL-33/ST2 signaling in infiltrating macrophages reduces the extent of acute BBB disruption after stroke. Intranasal IL-33 administration may represent a new strategy to reduce BBB leakage and infarct severity.
Authors
- Rehana K. Leak (ORCID: https://orcid.org/0000-0003-2817-7417)
- Connor Dufort (ORCID: https://orcid.org/0000-0002-7477-5023)
- Zhihong Du
- Z. Josh Huang (ORCID: https://orcid.org/0000-0003-0592-028X)
- Ana Rios Sigler (ORCID: https://orcid.org/0000-0002-5094-8073)
- Xiaoming Hu (ORCID: https://orcid.org/0000-0002-5857-6243)
- Ruyu Shi (ORCID: https://orcid.org/0009-0004-3230-2625)
- Fei Xu
- Miao Wang
Institutions
- Duquesne University (US)
- University of Pittsburgh (US)
- Geriatric Research Education and Clinical Center (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1186/s12974-024-03264-8
- Citations
- 18
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 4.33
Funders
- U.S. Department of Veterans Affairs
- National Institute of Neurological Disorders and Stroke