Construction of a tumor mutational burden-derived LncRNA prognostic computational framework associated with therapy sensitivity in skin cutaneous melanoma
This study elucidates the mechanistic role of STARD4-AS1 and its downstream targets in SKCM progression, highlighting the importance of the ADCY4/PRKACA/SOX10 pathway. The integration of computational analysis with experimental validation enhances the understanding of TILPI and its clinical implications. Overall, the findings underscore the potential of novel computational frameworks like TILPI in predicting and managing SKCM, particularly through targeting the ADCY4/PRKACA/SOX10 pathway.
Authors
- Gaohua Li (ORCID: https://orcid.org/0000-0003-0980-3355)
- Xinlin Huang
- Guoxin Li (ORCID: https://orcid.org/0000-0003-2773-7048)
- Zining Liu (ORCID: https://orcid.org/0000-0002-4355-6899)
- Tingting Wu (ORCID: https://orcid.org/0000-0003-3609-5016)
- Chuzhong Wei
- Yanan Wang (ORCID: https://orcid.org/0000-0002-2414-5103)
- Heping Li (ORCID: https://orcid.org/0000-0001-7814-0589)
- Lei Fan (ORCID: https://orcid.org/0000-0003-2084-7869)
- Pengcheng Gao
- Yuanbo Sun
- Jianwei Li (ORCID: https://orcid.org/0000-0003-4731-2186)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Mudanjiang Medical University (CN)
- Nanfang Hospital (CN)
- Anshan Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1186/s12967-024-05732-4
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Natural Science Foundation of Guangdong Province
- Foundation for Distinguished Young Talents in Higher Education of Guangdong
- Natural Science Foundation of Guangdong Province for Distinguished Young Scholars