Cholestatic insult triggers alcohol-associated hepatitis in mice
Our results support the hypothesis that cholestasis can be a critical contributor to the pathogenesis of AH. A combined treatment of EtOH and ANIT in mice presents biochemical, histological, and molecular features similar to those found in patients with AH, suggesting that this treatment scheme can be a useful model for studying Alcohol-associated Cholestasis and Hepatitis (AlChoHep).
Authors
- Michelle Ma (ORCID: https://orcid.org/0000-0002-3349-7346)
- Xiao‐Ming Yin (ORCID: https://orcid.org/0000-0002-8576-6093)
- Shengmin Yan (ORCID: https://orcid.org/0000-0003-4012-9557)
- Zhen Nan Lin (ORCID: https://orcid.org/0000-0002-9229-053X)
- Ailar Arasteh (ORCID: https://orcid.org/0000-0003-0893-9904)
Institutions
- Tulane University (US)
- Qualcomm (United Kingdom) (GB)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1097/hc9.0000000000000566
- Citations
- 5
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 2.12