Time-Dependent Association of Preinjury Anticoagulation on Traumatic Brain Injury-Induced Coagulopathy: A Retrospective, Multicenter Cohort Study
Despite more severe TBI signs and poorer outcomes, the preinjury anticoagulation group had significantly lower D-dimer levels, especially within 2 to 24 hours postinjury. Thus, D-dimer levels during this period may not reliably represent TBI severity in patients receiving anticoagulation therapy before injury. Preinjury anticoagulation was also associated with an elevated PT-INR and prolonged APTT from early to 24 hours postinjury, highlighting the importance of aggressive anticoagulant reversal early after injury.
Authors
- Takeshi Maeda (ORCID: https://orcid.org/0000-0002-2594-1128)
- Naoto Shiomi
- Kohei Haji (ORCID: https://orcid.org/0000-0002-1681-715X)
- Takahiro Onuki (ORCID: https://orcid.org/0009-0009-4914-9491)
- Kenya Kawakita
- Shoji Yokobori (ORCID: https://orcid.org/0000-0002-7409-704X)
- Shu Hasegawa
- Kazuya Matsuo (ORCID: https://orcid.org/0000-0001-6721-1353)
- Kotaro Oshio (ORCID: https://orcid.org/0000-0003-1236-9019)
- A. Miyata (ORCID: https://orcid.org/0000-0002-4010-9487)
- Motoki Inaji (ORCID: https://orcid.org/0000-0002-6759-5729)
- Nobukazu Komoribayashi (ORCID: https://orcid.org/0009-0002-9343-4862)
- Hiroshi Yatsushige
- Eiichi Suehiro (ORCID: https://orcid.org/0000-0001-5352-2214)
- Hiroshi Karibe
- Michiyasu Suzuki
- Shin Hirota
- Hideo Aihara (ORCID: https://orcid.org/0009-0000-9089-2345)
Institutions
- Nihon University (JP)
- Tokyo Medical and Dental University (JP)
- St. Marianna University School of Medicine (JP)
- Yamaguchi University (JP)
- Iwate Medical University (JP)
- Tsuchiura Kyodo General Hospital (JP)
- Japanese Red Cross Kumamoto Hospital (JP)
- Japanese Red Cross Kobe Hospital (JP)
- Himeji Medical Center (JP)
- Kagawa University Hospital (JP)
- National Hospital Organization (JP)
- Sendai City Hospital (JP)
- National Disaster Medical Center (JP)
- Saiseikai Shigaken Hospital (JP)
- Kobe University (JP)
- International University of Health and Welfare (JP)
- Nippon Medical School (JP)
- Teikyo University (JP)
Publication Details
- Journal
- Neurosurgery
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1227/neu.0000000000003238
- Citations
- 1
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 0.37
Funders
- CSL Behring
- Japan Society for the Promotion of Science