Shedding of nontyphoidal <i>Salmonella</i> by asymptomatic convalescing children under 5 years as a risk factor for invasive disease in Mukuru informal settlement in Nairobi, Kenya
Asymptomatic fecal shedding of nontyphoidal <i>Salmonella</i> (NTS) is hypothesized to contribute to the human-to-human transmission of NTS especially in low-resource settings which could lead to invasive disease among high-risk populations, especially children. Our findings reiterate the hypothesis that human reservoirs could be important in the transmission of nontyphoidal <i>Salmonella</i> in sub-Saharan Africa. This underscores the importance of developing infection prevention measures which could include vaccine deployment and improving water, sanitation and hygiene infrastructure.
Authors
- Antje Flieger (ORCID: https://orcid.org/0000-0003-3819-2979)
- Cecilia Mbae (ORCID: https://orcid.org/0000-0002-6933-248X)
- Sandra Simon (ORCID: https://orcid.org/0000-0002-7928-3503)
- Celestine Wairimu
- Michael Mugo (ORCID: https://orcid.org/0000-0003-1448-837X)
- Samuel Kariuki (ORCID: https://orcid.org/0000-0003-3209-9503)
- Kariuki Njaanake (ORCID: https://orcid.org/0000-0002-9684-4296)
- Stephan Fuchs (ORCID: https://orcid.org/0000-0002-1338-2699)
- Oliver Drechsel (ORCID: https://orcid.org/0000-0002-7661-2535)
- Kelvin Kering (ORCID: https://orcid.org/0000-0001-6399-7774)
- Torsten Semmler (ORCID: https://orcid.org/0000-0002-2225-7267)
- Marianne Mureithi (ORCID: https://orcid.org/0000-0001-9119-3167)
- Lothar Heinz Wieler (ORCID: https://orcid.org/0000-0003-4365-3717)
- Tanja Pilz
- Michael Pietsch (ORCID: https://orcid.org/0000-0003-4807-3244)
- Georgina Odityo
- Kristin Weber
- Andrea Thürmer
- Collins Kebenei
- Susan Kavai (ORCID: https://orcid.org/0000-0003-4617-9985)
Institutions
- University of Nairobi (KE)
- Hasso Plattner Institute (DE)
- Robert Koch Institute (DE)
- Kenya Medical Research Institute (KE)
- Kenya AIDS Vaccine Initiative (KE)
Publication Details
- Journal
- Journal of Clinical Microbiology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1128/jcm.00750-24
- Citations
- 8
- Primary Topic
- Salmonella and Campylobacter epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Deutsche Forschungsgemeinschaft
- Robert Koch Institut