Mouse innate resistance to <i>Neospora caninum</i> infection is driven by early production of IFNγ by NK cells in response to parasite ligands
Pathogen differences in host range are poorly understood at the molecular level even though even closely related pathogen species can have dramatically distinct host ranges. Here, we study two related parasite species that have a dramatic difference in their ability to infect mice. Here, we show that soluble proteins from these species determine one driver of this difference: induction of interferon gamma by cells of the innate immune system.
Authors
- Abigail E. Overacre-Delgoffe (ORCID: https://orcid.org/0000-0003-4027-3487)
- Jon P. Boyle (ORCID: https://orcid.org/0000-0003-0000-9243)
- Rachel S. Coombs
- Timothy W. Hand (ORCID: https://orcid.org/0000-0002-2684-9462)
- Amrita Bhattacharjee (ORCID: https://orcid.org/0000-0001-5613-8963)
Institutions
- University of Pittsburgh (US)
Publication Details
- Journal
- mSphere
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1128/msphere.00255-24
- Citations
- 1
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.52
Funders
- Damon Runyon Cancer Research Foundation
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- Children's Hospital of Pittsburgh