LOW 25OHD IN ENDOMETRIOSIS- RISK FACTOR OR CONSEQUENCE?!

Women with endometriosis have a lower 25OHD, a higher 1.25OHD, and total calcium levels in the bloodstream compared to the control group. Usually, a low concentration of 25OHD is characterized by low/normal 1.25OHD and hypocalcemia. Hypercalcemia in the study group may be attributed to increased levels of active vitamin D- 1.25OHD, which seems to be the result of a higher conversion rate of 25OHD to 1.25OHD in the endometrium of women with endometriosis. Removal of endometriotic heterotopies was followed by significant changes, which could indicate that the levels of vitamin D metabolites have been influenced by endometriosis. It is reasonable to conclude, that diminished levels of 25OHD might be interpreted as an outcome of a high demand in endometriosis, instead of a risk factor.