SPAG6 overexpression decreases the pro-apoptotic effect of daunorubicin in acute myeloid leukemia cells through the ROS/JNK MAPK axis in a GSTP1-dependent manner
In conclusion, our experiments suggested that upregulated SPAG6 might mitigate the pro-apoptotic effects of DNR through ROS/JNK MAPK axis in a GSTP1-dependent manner.
Authors
- Lin Liu (ORCID: https://orcid.org/0000-0002-7888-3785)
- Jie Luo (ORCID: https://orcid.org/0000-0002-3276-115X)
- Ding Li (ORCID: https://orcid.org/0000-0002-3581-7630)
- Jiamin Zhang (ORCID: https://orcid.org/0000-0001-5919-002X)
- Shirui Pan
- Jiaxiu Yin (ORCID: https://orcid.org/0000-0002-9831-1573)
- Rong Su (ORCID: https://orcid.org/0009-0003-4765-6859)
- Haiqiu Zhao
- Jing Luo (ORCID: https://orcid.org/0009-0008-3540-4191)
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-23
- DOI
- https://doi.org/10.3389/fphar.2024.1390456
- Citations
- 4
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Chongqing Medical University