Prognostic implications of a CD8+ TEMRA to CD4+Treg imbalance in mandibular fracture healing: a prospective analysis of immune profiles
Our analysis of mandibular fracture cases confirms our initial hypothesis derived from long bone fracture healing: monitoring the T<sub>EMRA</sub> to T<sub>reg</sub> ratio in preoperative blood can be an early indicator of patients at risk of impaired bone healing. Radiologic follow-up enabled us to detect healing complications that might not be detected by clinical assessment only. This study highlights the potential of individual immune profiles to predict successful healing and may form the basis for future strategies to manage healing complications.
Authors
- Sven Geißler (ORCID: https://orcid.org/0000-0002-8750-6324)
- Kento Odaka (ORCID: https://orcid.org/0000-0002-4717-533X)
- Ioanna Maria Dimitriou (ORCID: https://orcid.org/0000-0002-2299-2042)
- Melanie Ort
- Katharina Schmidt‐Bleek (ORCID: https://orcid.org/0000-0002-5719-0867)
- Mathias Streitz
- Jan Oliver Voß (ORCID: https://orcid.org/0000-0002-1760-2599)
- Georg N. Duda (ORCID: https://orcid.org/0000-0001-7605-3908)
- Simon Reinke (ORCID: https://orcid.org/0000-0002-3451-9383)
- Steffen Koerdt (ORCID: https://orcid.org/0000-0002-8679-8775)
- Max Heiland (ORCID: https://orcid.org/0000-0002-4987-2913)
- Fabio Pivetta
- Aboelyazid Elkilany
Institutions
- Friedrich-Loeffler-Institut (DE)
- Tokyo Dental College (JP)
- Humboldt-Universität zu Berlin (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-23
- DOI
- https://doi.org/10.3389/fimmu.2024.1476009
- Citations
- 6
- Primary Topic
- Facial Trauma and Fracture Management
- Type
- article
- Field-Weighted Citation Impact
- 3.44
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Berlin Institute of Health