The mechanism underlying B-cell developmental dysfunction in Kawasaki disease based on single-cell transcriptomic sequencing
Our results indicate that the immune premature HSPCs accompanied with the abnormal expression dynamics of cell cycle and SPI1 genes are the mechanism underlying B cell developmental dysfunction in KD patients.
Authors
- Tingting Xiao (ORCID: https://orcid.org/0000-0001-7311-4496)
- Lijian Xie (ORCID: https://orcid.org/0000-0002-0328-6820)
- Xunwei Jiang
- Liqin Chen (ORCID: https://orcid.org/0000-0002-2222-4924)
- Guohui Ding (ORCID: https://orcid.org/0000-0002-2888-1335)
- Guang Li (ORCID: https://orcid.org/0000-0001-9268-0442)
- Zhen Wang (ORCID: https://orcid.org/0000-0001-8108-627X)
- Wei Liu (ORCID: https://orcid.org/0009-0008-1621-4093)
- Min Huang (ORCID: https://orcid.org/0000-0001-9019-0044)
- Qingzhu Qiu
- Qiuping Lin (ORCID: https://orcid.org/0000-0002-8745-486X)
- Libing Shen
- Sirui Song
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Jinshan Hospital of Fudan University (CN)
- Shanghai Children's Hospital (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-23
- DOI
- https://doi.org/10.3389/fimmu.2024.1438640
- Citations
- 5
- Primary Topic
- Kawasaki Disease and Coronary Complications
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality