Enhancement of a one-step membrane technique for the treatment of large bone defects by pre-seeding the membrane with CD8 lymphocyte depleted bone marrow mononuclear cells in a rat femoral defect model
Depleting CD8+ cells from BMC before colonizing hADM significantly improved bone healing, likely due to changes in the local mediator environment. This suggests that preoperative colonization with CD8+-depleted BMC could enhance the one-step membrane technique.
Authors
- Katrin Schröder (ORCID: https://orcid.org/0000-0002-3099-526X)
- İngo Marzi (ORCID: https://orcid.org/0000-0003-3677-2910)
- Sébastien Behr (ORCID: https://orcid.org/0000-0002-8650-6365)
- Andreas Kammerer
- Jonas Neijhoft (ORCID: https://orcid.org/0000-0003-2040-0100)
- René D. Verboket (ORCID: https://orcid.org/0000-0003-1086-4016)
- Marissa Penna-Martinez (ORCID: https://orcid.org/0000-0002-6767-8057)
- Christoph Nau (ORCID: https://orcid.org/0009-0004-0872-1803)
- Inna Schaible
- Dirk Henrich (ORCID: https://orcid.org/0000-0002-9728-4032)
- Pia Stützle
- Sabatian Fees
Institutions
- Goethe University Frankfurt (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-23
- DOI
- https://doi.org/10.3389/fimmu.2024.1488611
- Citations
- 2
- Primary Topic
- Bone fractures and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.77