Non-classical monocyte levels correlate negatively with HIV-associated cerebral small vessel disease and cognitive performance
Elevated levels of NCMs may contribute to neuroinflammation, CSVD and subsequent cognitive impairment. This finding is of particular relevance in aging PWH as both HIV and aging are associated with increased levels of NCMs. NCMs may serve as a potential biomarker to address these comorbidities. Further longitudinal studies are needed to evaluate whether changes in NCM levels are associated with changes in CSVD burden and cognitive impairment.
Authors
- Karli R. Sutton
- Giovanni Schifitto (ORCID: https://orcid.org/0000-0002-2115-4143)
- Md Nasir Uddin (ORCID: https://orcid.org/0000-0002-5887-1322)
- Mae Covacevich Vidalle
- Zachary D. Boodoo
- Alicia Tyrell (ORCID: https://orcid.org/0009-0002-1197-345X)
- Miriam T. Weber
- Bogachan Sahin (ORCID: https://orcid.org/0000-0002-2753-2504)
- Henry Z. Wang
- Madalina E. Tivarus (ORCID: https://orcid.org/0000-0001-7481-5913)
- Meera V. Singh (ORCID: https://orcid.org/0000-0001-8481-1668)
- Jianhui Zhong (ORCID: https://orcid.org/0000-0002-8887-8103)
- Sanjay B. Maggirwar (ORCID: https://orcid.org/0000-0003-4948-917X)
- Angelique N. Peterson
- Lu Wang (ORCID: https://orcid.org/0000-0002-6515-1075)
- Xing Qiu (ORCID: https://orcid.org/0000-0002-2330-3544)
Institutions
- George Washington University (US)
- University of Rochester (US)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-10-23
- DOI
- https://doi.org/10.3389/fcimb.2024.1405431
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.99
Funders
- Medical Center, University of Rochester
- National Institute on Aging
- National Institute of Mental Health
- National Institute of Allergy and Infectious Diseases