Deep Phenotyping of a Mouse Model for Hearing Instability Disorders
Deep phenotyping of DE17.5 mice demonstrates changes in EP and EH compared with control; however, the HI phenotype was associated with differential ion homeostasis gene expression and increased macrophage activation in the SV. This provides potential further insights into the underlying pathogenesis and possible immunologic contributions of HI in humans.
Authors
- Dillon Strepay (ORCID: https://orcid.org/0000-0003-2120-4857)
- Samuel Mawuli Adadey (ORCID: https://orcid.org/0000-0002-1993-2786)
- Rafal T. Olszewski (ORCID: https://orcid.org/0000-0001-8134-9009)
- J. Dixon Johns (ORCID: https://orcid.org/0000-0002-5495-5713)
- Michael Hoa (ORCID: https://orcid.org/0000-0001-7469-2909)
Institutions
- National Institutes of Health (US)
- Georgetown University (US)
- National Institute on Deafness and Other Communication Disorders (US)
Publication Details
- Journal
- Otology & Neurotology
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1097/mao.0000000000004345
- Citations
- 2
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders