Normalized Interferon Signatures and Clinical Improvements by IFNAR1 Blocking Antibody (Anifrolumab) in Patients with Type I Interferonopathies
These results verify a causal role of IFN-I signaling in type-I Interferonopathies SAVI and CANDLE and suggests Anifrolumab as an important new treatment option in autoinflammatory diseases with elevated IFN-I induced gene expression. Genia Kretzschmar, Laura Piñero Páez, and Ziyang Tan are shared-first authors. Sara Alehashemi, AnnaCarin Horne, and Petter Brodin are co-senior author.
Authors
- Anna James (ORCID: https://orcid.org/0000-0003-2698-8419)
- Sara Alehashemi (ORCID: https://orcid.org/0000-0002-6531-6108)
- Marie Fischer (ORCID: https://orcid.org/0000-0001-9047-3650)
- AnnaCarin Horne (ORCID: https://orcid.org/0000-0002-2878-4463)
- Tadepally Lakshmikanth (ORCID: https://orcid.org/0000-0001-7256-5770)
- Ziyang Tan (ORCID: https://orcid.org/0000-0002-7205-4978)
- Jaromír Mikeš (ORCID: https://orcid.org/0000-0002-9941-7855)
- Raphaela Goldbach‐Mansky (ORCID: https://orcid.org/0000-0001-7865-5769)
- Anette Johnsson (ORCID: https://orcid.org/0000-0003-2944-1099)
- Petter Brodin (ORCID: https://orcid.org/0000-0002-8103-0046)
- Karin Palmblad (ORCID: https://orcid.org/0000-0003-1197-5201)
- Genia Kretzschmar
- Constantin Habimana Mugabo
- Yang Chen (ORCID: https://orcid.org/0000-0003-0164-7079)
- Jun Wang (ORCID: https://orcid.org/0000-0003-3509-0790)
- Laura González (ORCID: https://orcid.org/0000-0001-6000-241X)
- Laura Piñero Páez
Institutions
- Karolinska University Hospital (SE)
- Hammersmith Hospital (GB)
- Karolinska Institutet (SE)
- National Institute of Allergy and Infectious Diseases (US)
- Imperial College London (GB)
Publication Details
- Journal
- Journal of Clinical Immunology
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1007/s10875-024-01826-2
- Citations
- 22
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.29
Funders
- Göran Gustafssons Stiftelser
- Svenska Sällskapet för Medicinsk Forskning
- Karolinska Institutet
- Vetenskapsrådet
- Uppsala Multidisciplinary Center for Advanced Computational Science