Population Pharmacokinetic Quantification of CYP2D6 Activity in Codeine Metabolism in Ambulatory Surgical Patients for Model-Informed Precision Dosing
Our final model leads the way in implementing model-informed precision dosing in codeine therapy and identifies the use of genetic testing as an integral component in the effort to implement rational pharmacotherapy with codeine.
Authors
- Satu Poikola
- Janne T. Backman (ORCID: https://orcid.org/0000-0002-9577-2788)
- Vesa Kontinen (ORCID: https://orcid.org/0000-0003-2603-3807)
- Mikko Niemi (ORCID: https://orcid.org/0000-0003-4550-2189)
- Mikko Neuvonen (ORCID: https://orcid.org/0000-0002-7627-1638)
- Klaus Tapio Olkkola (ORCID: https://orcid.org/0000-0001-7872-8665)
- Johanna I. Kiiski (ORCID: https://orcid.org/0000-0002-4089-7209)
- Muhammad Waqar Ashraf (ORCID: https://orcid.org/0000-0002-9947-1579)
- Teijo I. Saari (ORCID: https://orcid.org/0000-0003-1225-4561)
Institutions
- University of Helsinki (FI)
- University of Turku (FI)
- Helsinki University Hospital (FI)
- Jorvi Hospital (FI)
- Turku University Hospital (FI)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1007/s40262-024-01433-9
- Citations
- 5
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 3.21
Funders
- Helsingin ja Uudenmaan Sairaanhoitopiiri
- Suomen Kulttuurirahasto
- Turun Yliopisto
- Sigrid Juséliuksen Säätiö
- Varsinais-Suomen Sairaanhoitopiiri
- Turun yliopiston tutkijakoulu