Single-cell transcriptome analysis identifies a novel tumor-associated macrophage subtype predicting better prognosis in pancreatic ductal adenocarcinoma
Our study used two prognosis-favorable genes to divide M2-like TAMs of PDAC into anti-tumor bM2-like TAMs and pro-tumor mM2-like TAMs. The bM2-like TAMs activate T cells through ALCAM/CD6 and generate prognosis-favorable αSMA+ myofibroblasts through secreting TGFβ, which brings insight into heterogeneity of TAMs, prognosis prediction and immunotherapy of PDAC.
Authors
- Zichun Hua (ORCID: https://orcid.org/0000-0001-7962-0402)
- Bo Zhu (ORCID: https://orcid.org/0000-0001-5856-6320)
- Xiaonan Wang (ORCID: https://orcid.org/0000-0003-3759-778X)
- Dongyi Li (ORCID: https://orcid.org/0000-0003-1814-3096)
Institutions
- China Pharmaceutical University (CN)
- Henan Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2024-10-23
- DOI
- https://doi.org/10.3389/fcell.2024.1466767
- Citations
- 9
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.54
Funders
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province