Overexpression of a disintegrin and metalloproteinase 9 (ADAM9) in relation to poor prognosis of patients with oral squamous cell carcinoma
This study investigates the expressions of ADAM9, CDCP1 and t-PA in OSCC and their impacts on patient prognosis. Previous research has demonstrated the overexpression of ADAM9 and activation of plasminogen activator in OSCC, but CDCP1's role remains unexplored. While these biomolecules are known to contribute to lung cancer metastasis, their concurrent expressions in OSCC have not been thoroughly examined. Our aim is to assess the expressions of ADAM9, CDCP1, and t-PA in OSCC specimens, compare them with normal oral tissues, and explore their correlation with OSCC's clinicopathological features and patient survival outcomes.
Authors
- Lang Cheng (ORCID: https://orcid.org/0000-0002-1102-0336)
- Shuangjiang Wu (ORCID: https://orcid.org/0000-0001-5103-0849)
- Suttichai Krisanaprakornkit (ORCID: https://orcid.org/0000-0001-9189-0333)
- Anupong Makeudom
- Tao Luo (ORCID: https://orcid.org/0000-0002-4144-4500)
- Lei Wang (ORCID: https://orcid.org/0000-0003-0734-7026)
Institutions
- Southwest Medical University (CN)
- Mae Fah Luang University (TH)
- Affiliated Hospital of Southwest Medical University (CN)
- The Fifth People's Hospital of Anyang (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1007/s12672-024-01422-1
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.28
Funders
- Southwest Medical University
- Thailand Science Research and Innovation
- Affiliated Hospital of Southwest Medical University