Antimutagenic and anticoagulant therapeutic effects of Ag/Ag2O nanoparticles from Olea europaea leaf extract: mitigating metribuzin-induced hepato-and nephrotoxicity
Ag/Ag₂O NPs synthesized via green methods using olive leaf extract effectively mitigated metribuzin-induced toxicity, especially at lower doses, by improving oxidative stress markers and hematological and biochemical profiles. Dose optimization is crucial to maximize therapeutic benefits and minimize adverse effects, underscoring their potential in treating chemical-induced toxicity.
Authors
- Salah Eddine Laouini (ORCID: https://orcid.org/0000-0002-6609-4623)
- Ali Tliba
- Ahmed Barhoum
- Ifriqya Medila (ORCID: https://orcid.org/0000-0001-6766-5822)
- Manel Azzi
- Abderrhmane Bouafia (ORCID: https://orcid.org/0000-0001-5266-7796)
- Mikhaël Bechelany (ORCID: https://orcid.org/0000-0002-2913-2846)
- Ibtissam Laib (ORCID: https://orcid.org/0000-0002-9521-3003)
- Huda Alsaeedi
- David Cornu (ORCID: https://orcid.org/0000-0002-5205-3038)
Institutions
- École Nationale Supérieure de Chimie de Montpellier (FR)
- Centre National de la Recherche Scientifique (FR)
- Gulf University for Science & Technology (KW)
- King Saud University (SA)
- Centre Hospitalo-Universitaire Bab El Oued (DZ)
- Institut Européen des Membranes (FR)
- Helwan University (EG)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-23
- DOI
- https://doi.org/10.3389/fphar.2024.1485525
- Citations
- 27
- Primary Topic
- Moringa oleifera research and applications
- Type
- article
- Field-Weighted Citation Impact
- 16.19
Funders
- King Saud University