Molecular mechanisms underlying glucose-dependent insulinotropic polypeptide secretion in human duodenal organoids
The newly generated human organoid K cell model enables transcriptomic and functional characterisation of nutrient-sensing pathways involved in human GIP secretion. Both calcium-sensing receptor (CASR) and G protein-coupled receptor 142 (GPR142) contribute to protein-stimulated GIP secretion. This model will be further used to identify potential targets for modulation of native GIP secretion in diabetes and obesity.
Authors
- Adam Davison
- Fiona M. Gribble (ORCID: https://orcid.org/0000-0002-4232-2898)
- Constanza Alcaino (ORCID: https://orcid.org/0000-0001-9595-4330)
- Frank M. Reimann (ORCID: https://orcid.org/0000-0001-9399-6377)
- Rula Bany Bakar (ORCID: https://orcid.org/0000-0002-5643-0195)
- Marta Santos-Hernández (ORCID: https://orcid.org/0000-0003-0156-242X)
- Richard G. Kay (ORCID: https://orcid.org/0000-0002-3827-8687)
- Nunzio Guccio
- Emily L. Miedzybrodzka (ORCID: https://orcid.org/0000-0001-9201-0860)
- Christopher A. Smith
Institutions
- University of Cambridge (GB)
- MRC Centre for Regenerative Medicine (GB)
- Addenbrooke's Hospital (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Diabetologia
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1007/s00125-024-06293-3
- Citations
- 10
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 5.73
Funders
- Wellcome Trust
- Cancer Research UK
- European Association for the Study of Diabetes
- Medical Research Council
- Cambridge Institute for Medical Research, University of Cambridge
- Cancer Research UK Cambridge Institute, University of Cambridge