cAMP driven UCP1 induction in human adipocytes requires ATGL-catalyzed lipolysis
UCP1 transcription is known to be stimulated by transcription factors activated downstream of cAMP-dependent protein kinases. Here we demonstrate that UCP1 transcription can also be acutely induced through PPARγ-activation. Moreover, both pathways are activated in human adipocytes in response to cAMP, synergistically inducing UCP1 expression. The stimulation of PPARγ in response to cAMP may result from the production of natural PPARγ activating ligands through ATGL-mediated lipolysis.
Authors
- Javier Solivan-Rivera (ORCID: https://orcid.org/0000-0002-3238-485X)
- Silvia Corvera (ORCID: https://orcid.org/0000-0002-0009-4129)
- Anand Desai (ORCID: https://orcid.org/0000-0002-3366-0801)
- Qin Yang (ORCID: https://orcid.org/0000-0002-0114-4407)
- Zinger Yang (ORCID: https://orcid.org/0000-0001-8543-4841)
- Tiffany DeSouza (ORCID: https://orcid.org/0000-0001-6237-1139)
Institutions
- University of Massachusetts Chan Medical School (US)
- Institute of Molecular Medicine (IN)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1016/j.molmet.2024.102051
- Citations
- 10
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.27
Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases