WIF-1 contributes to lupus-induced neuropsychological deficits via the CRYAB/STAT4-SHH axis
In conclusion, WIF-1 exacerbates lupus-induced cognitive dysfunction in mice by triggering aberrant microglial activation and BBB disruption through the CRYAB/STAT4-SHH axis, highlighting the potential therapeutic effects of SDMA for the treatment of NPSLE.
Authors
- Huan Dou (ORCID: https://orcid.org/0000-0001-6330-398X)
- Xiangyu Cao (ORCID: https://orcid.org/0000-0002-4591-3220)
- Yayi Hou (ORCID: https://orcid.org/0000-0002-1152-9132)
- Tianshu Zhang (ORCID: https://orcid.org/0000-0001-7116-6903)
- Jun Liang
- Chenghao Zhang (ORCID: https://orcid.org/0000-0001-8564-9236)
- Yu Fan (ORCID: https://orcid.org/0000-0001-8917-7600)
- Xinyi Xu (ORCID: https://orcid.org/0000-0002-3837-4548)
- Liping Tan (ORCID: https://orcid.org/0000-0002-1773-0435)
Institutions
- Nanjing University of Chinese Medicine (CN)
- China Pharmaceutical University (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1186/s13075-024-03420-8
- Citations
- 3
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Bethune Charitable Foundation
- National Natural Science Foundation of China
- Nanjing University