A Case of Severe Cushing Syndrome due to Metastatic Adrenocortical Carcinoma Treated With Osilodrostat

Although osilodrostat is currently only approved for use in pituitary Cushing disease, we found it effective in off-label use to treat Cushing syndrome due to ACC. Using a block-and-replace treatment strategy was a practical intervention after development of adrenal insufficiency.

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Publication Details

Journal
AACE Clinical Case Reports
Published
2024-10-23
DOI
https://doi.org/10.1016/j.aace.2024.10.005
Citations
2
Primary Topic
Adrenal and Paraganglionic Tumors
Type
article
Field-Weighted Citation Impact
1.15
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article

A Case of Severe Cushing Syndrome due to Metastatic Adrenocortical Carcinoma Treated With Osilodrostat

Kathleen Ruddiman, Alex K Bonnecaze, Catherine Price
2 citations
AACE Clinical Case Reports
Adrenal and Paraganglionic Tumors
1.15
article

A Case of Severe Cushing Syndrome due to Metastatic Adrenocortical Carcinoma Treated With Osilodrostat

Kathleen Ruddiman, Alex K Bonnecaze, Catherine Price
article en
2 citations

Abstract

Although osilodrostat is currently only approved for use in pituitary Cushing disease, we found it effective in off-label use to treat Cushing syndrome due to ACC. Using a block-and-replace treatment strategy was a practical intervention after development of adrenal insufficiency.

AACE Clinical Case ReportsVol. 11(1)
Sandhills Community College (US), FirstHealth of the Carolinas (US), Wake Forest University (US)
Good health and well-being
Openalex Percentile: Top 20%
Adrenal and Paraganglionic Tumors
1.15
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