A Discrete Four‐Stranded β‐Sheet through Catenation of M <sub>2</sub> L <sub>2</sub> Metal–Peptide Rings
Methods for precisely constructing a β-sheet assembly with number-defined strands in solution remains quite limited due to its intense aggregation property. Here, we report the precise construction of a four-stranded anti-parallel β-sheet by utilizing a non-covalent approach. This was achieved by folding and assembly of Ag<sup>+</sup> and a pentapeptide (1) with the Ala-<sup>D</sup>3pa-Gly-3pa-Val (3pa: β-(3-pyridyl)-alanine) sequence, which was designed to form an interlocking Ag<sub>2</sub>(1)<sub>2</sub> ring through metal cross-linking of the side chains. NMR analyses and X-ray crystallographic studies characterized the structure of the discrete β-sheet assembly as well as the remarkable structural selectivity in terms of strands' number, orientation and the sheet type.
Authors
- Makoto Fujita (ORCID: https://orcid.org/0000-0001-6105-7340)
- Tomohisa Sawada (ORCID: https://orcid.org/0000-0003-2361-9466)
- Eisuke Tsunekawa (ORCID: https://orcid.org/0000-0002-8646-9787)
Institutions
- Tokyo Institute of Technology (JP)
- National Institutes of Natural Sciences (JP)
- Japan Science and Technology Agency (JP)
- Life Science Institute (JP)
- Institute for Molecular Science (JP)
- Institute of Science Tokyo (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1002/anie.202416442
- Citations
- 5
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Japan Society for the Promotion of Science
- Precursory Research for Embryonic Science and Technology