Reductions in the white–gray functional connectome in preclinical Alzheimer's disease and their associations with amyloid and cognition
Preclinical Alzheimer's disease (AD) subjects showed lower functional connectivity in specific white-gray matter (WM-GM) pairs and reduced segregations of control, dorsal attention, and somatomotor networks. A major portion of the reduced connectivity and network segregations were linked to elevated amyloid beta load. Only one WM-GM pair's reduced connectivity was linearly correlated with impaired cognitive composite scores. AD dementia showed more extensive reductions in connectivity, network integration, and segregation, with stronger associations with amyloid elevation and cognitive impairment. The WM-GM functional connectome offers a distinct perspective for understanding changes in brain functional architecture throughout the AD continuum.
Authors
- John C. Gore (ORCID: https://orcid.org/0000-0002-9480-0900)
- Baxter P. Rogers (ORCID: https://orcid.org/0000-0002-5666-2797)
- Yurui Gao (ORCID: https://orcid.org/0000-0002-4339-5351)
- Adam W. Anderson (ORCID: https://orcid.org/0000-0002-3788-6138)
- Muwei Li (ORCID: https://orcid.org/0000-0003-3596-9287)
- Kurt G. Schilling (ORCID: https://orcid.org/0000-0003-3686-7645)
- Soyoung Choi (ORCID: https://orcid.org/0000-0001-7165-4691)
- Bennett A. Landman (ORCID: https://orcid.org/0000-0001-5733-2127)
- Zhaohua Ding (ORCID: https://orcid.org/0000-0002-1805-2955)
- Zhongliang Zu (ORCID: https://orcid.org/0000-0001-7361-7480)
- Yu Zhao (ORCID: https://orcid.org/0000-0002-2814-591X)
- Lyuan Xu (ORCID: https://orcid.org/0000-0002-9791-0806)
Institutions
- Vanderbilt University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1002/alz.14334
- Citations
- 11
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.77
Funders
- Vanderbilt University
- Vanderbilt Institute for Clinical and Translational Research
- Vanderbilt Memory and Alzheimer's Center
- National Institutes of Health
- National Institute on Aging
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
- National Institute of Biomedical Imaging and Bioengineering