Case report: Acute liver failure during deferasirox therapy and the potential role of pharmacogenetics
The precise mechanism by which toxicity developed in this case remains unclear and is likely multifactorial. However, it is probable that the presence of SNPs in the gene <i>ABCC2</i> played a substantial role. Our findings align with those of previously published reports of remarkably similar cases, where patients also exhibited genetic variants in the gene <i>ABCC2</i>.
Authors
- Birte Möhlendick (ORCID: https://orcid.org/0000-0001-9093-8585)
- Lydia Rink
- Christian Dohna‐Schwake (ORCID: https://orcid.org/0000-0001-8973-5406)
- Belén García-Fariña
- Virginia Santarini
- Marco Westkemper
Institutions
- Essen University Hospital (DE)
- Klinikum Dortmund (DE)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-23
- DOI
- https://doi.org/10.3389/fphar.2024.1477755
- Citations
- 6
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.63
Funders
- Universität Duisburg-Essen